GermanWikipedia - /page/entry.mu

Micron Document

<!DOCTYPE html>

<title>Transcortin</title>

</head>

<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Transcortin</span></h1>

</header>

</div>

<th colspan="3" style="background:#90EE90; color:#202122;">Transcortin

</th></tr>

<tr>

<p>Vorhandene Strukturdaten: <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2VDX">2VDX</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2VDY">2VDY</a></span>

</p>

</td></tr>

<tr>

<th colspan="3" style="background:#90EE90; color:#202122;;">Eigenschaften des menschlichen Proteins

</th></tr>

<tr>

<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>

</td>

<td colspan="2" style="text-align:center;">383 Aminosäuren

</td></tr>

<tr>

<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner

</th></tr>

<tr>

</td>

<td colspan="2" class="" style="text-align:center;"><i><a rel="nofollow" class="external text" href="https://www.genenames.org/tools/search/#!/all?query=1540">SERPINA6</a></i>

</td></tr>

<tr>

<td>Externe IDs

</td>

<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P08185">P08185</a></li></ul>

</td></tr>

<tr>

<th colspan="3" style="background:#90EE90; color:#202122;">Inhibitorklassifikation

</th></tr>

<tr>

<td><a href="MEROPS" title="MEROPS">MEROPS</a>

</td>

</td></tr>

<tr>

<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen

</th></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;">Homologie-Familie

</td>

<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=P08185">Hovergen</a>

</td></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;">Übergeordnetes <a href="Taxon" title="Taxon">Taxon</a>

</td>

<td colspan="2" style="text-align:center;"><a href="S%C3%A4ugetiere" title="Säugetiere">Säugetiere</a><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>

</td></tr>

<tr>

<td colspan="3" style="background:#90EE90; color:#202122; text-align:center;"><a href="Homologie_(Genetik)#Homologie_zwischen_verdoppelten_oder_fremden_Genen" title="Homologie (Genetik)">Orthologe</a>

</td></tr>

<tr>

</td>

<td style="background:#C3FDB8; color:#202122; text-align:center;">Mensch

</td>

<td style="background:#C3FDB8; color:#202122; text-align:center;">Hausmaus

</td></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;"><a href="Entrez_Gene" title="Entrez Gene">Entrez</a>

</td>

</td>

</td></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;"><a href="Ensembl" title="Ensembl">Ensembl</a>

</td>

</td>

<td><span class=""><small><small><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000060807;db=core">ENSMUSG00000060807</a></small></small></span>

</td></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;"><a href="UniProt" title="UniProt">UniProt</a>

</td>

</td>

</td></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (mRNA)

</td>

</td>

</td></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (Protein)

</td>

</td>

</td></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;"><a href="Genlocus" title="Genlocus">Genlocus</a>

</td>

</td>

</td></tr>

<tr>

<td style="background:#C3FDB8; color:#202122;"><a href="PubMed" title="PubMed">PubMed</a>-Suche

</td>

</td>

</p>

</td></tr></tbody></table><p><span class="editoronly" style="display:none;"></span>

</p><p><b>Transcortin</b> (<b>CBG</b>, von <a href="Englische_Sprache" title="Englische Sprache">engl.:</a> <i>Corticosteroid binding globulin</i>) ist ein <a href="Plasmaprotein" title="Plasmaprotein">Plasmaprotein</a> in <a href="S%C3%A4ugetiere" title="Säugetiere">Säugetieren</a>, dessen Aufgabe die Bindung und der Transport von <a href="Glukokortikoid" class="mw-redirect" title="Glukokortikoid">Glukokortikoiden</a> und <a href="Progesteron" title="Progesteron">Progesteron</a> im Blut ist. Es gehört zur Gruppe der <a href="Globuline" title="Globuline">α₁-Globuline</a>. Die Produktion findet in der <a href="Leber" title="Leber">Leber</a> statt und wird von <a href="%C3%96strogen" class="mw-redirect" title="Östrogen">Östrogen</a> reguliert.

</p><p>Transcortin hat eine hohe <a href="Affinit%C3%A4t_(Biochemie)" title="Affinität (Biochemie)">Affinität</a> für <a href="Cortisol" title="Cortisol">Cortisol</a>, von dem vermutet wird, dass es nur in seiner nicht an Transcortin gebundenen Form biologisch aktiv ist. Etwa 75 % des Cortisols im Kreislauf sind an Transcortin gebunden.

</p><p>Die Molekülmasse von Transcortin beträgt 52000 <a href="Dalton_(Einheit)" class="mw-redirect" title="Dalton (Einheit)">Dalton</a>, die normale Konzentration im Serum beträgt etwa 37 mg/l, kann sich aber in der <a href="Schwangerschaft" title="Schwangerschaft">Schwangerschaft</a> oder nach Einnahme von <a href="Ovulationshemmer" class="mw-redirect" title="Ovulationshemmer">Ovulationshemmern</a> verdoppeln. Bei einer <a href="Leberzirrhose" title="Leberzirrhose">Leberzirrhose</a> verringert sich die Konzentration.

</p>

<div class="mw-heading mw-heading2"><h2 id="Literatur">Literatur</h2></div>

<ul><li>A. Zhou, Z. Wei, P. L. Stanley, R. J. Read, P. E. Stein, R. W. Carrell: <i>The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release.</i> In: <i>J. Mol. Biol.</i> 380 (1), June 2008, S. 244–251. <a href="https://doi.org/10.1016/j.jmb.2008.05.012" class="extiw external" title="doi:10.1016/j.jmb.2008.05.012">doi:10.1016/j.jmb.2008.05.012</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18513745?dopt=Abstract">PMID 18513745</a>.</li>

<li>G. L. Hammond, C. L. Smith, I. S. Goping, D. A. Underhill, M. J. Harley, J. Reventos, N. A. Musto, G. L. Gunsalus, C. W. Bardin: <i>Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors.</i> In: <i>Proc Natl Acad Sci U S A.</i> 84 (15), Aug 1987, S. 5153–5157. <a href="https://doi.org/10.1073/pnas.84.15.5153" class="extiw external" title="doi:10.1073/pnas.84.15.5153">doi:10.1073/pnas.84.15.5153</a>. <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC298812/">PMC 298812</a> (freier Volltext). <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/3299377?dopt=Abstract">PMID 3299377</a>.</li>

<li>B. C. Byth, G. D. Billingsley, D. W. Cox: <i>Physical and genetic mapping of the serpin gene cluster at 14q32.1: allelic association and a unique haplotype associated with alpha 1-antitrypsin deficiency.</i> In: <i>Am J Hum Genet.</i> 55 (1), Jul 1994, S. 126–133. <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1918218/">PMC 1918218</a> (freier Volltext). <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/7912884?dopt=Abstract">PMID 7912884</a>.</li>

<li>E. Edward Bittar, Neville Bittar: <i>Molecular and Cellular Endocrinology.</i> Elsevier, 1997, ISBN 1-55938-815-3, S. 238.</li>

<li><i>Principles and Practice of Endocrinology and Metabolism.</i> Lippincott Williams & Wilkins, 2001, ISBN 0-7817-1750-7, S. 712.</li>

<li>Negi: <i>Introduction To Endocrinology.</i> PHI Learning Pvt., 2009, ISBN 978-81-203-3850-0, S. 268.</li>

<li>J. F. Dunn, B. C. Nisula, D. Rodbard: <i>Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma.</i> In: <i>The Journal of Clinical Endocrinology and Metabolism.</i> 53 (1), July 1981, S. 58–68. <a href="https://doi.org/10.1210/jcem-53-1-58" class="extiw external" title="doi:10.1210/jcem-53-1-58">doi:10.1210/jcem-53-1-58</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/7195404?dopt=Abstract">PMID 7195404</a>.</li>

<li>B. U. Musa, U. S. Seal, R. P. Doe: <i>Elevation of certain plasma proteins in man following estrogen administration: a dose-response relationship.</i> In: <i>J. Clin. Endocrinol. Metab.</i> 25 (9), September 1965, S. 1163–1166. <a href="https://doi.org/10.1210/jcem-25-9-1163" class="extiw external" title="doi:10.1210/jcem-25-9-1163">doi:10.1210/jcem-25-9-1163</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/4284083?dopt=Abstract">PMID 4284083</a>.</li>

<li>D. J. Torpy, B. A. Lundgren, J. T. Ho, J. G. Lewis, H. S. Scott, V. Mericq: <i>CBG Santiago: a novel CBG mutation.</i> In: <i>J. Clin. Endocrinol. Metab.</i> 97 (1), January 2012, S. E151–E155. <a href="https://doi.org/10.1210/jc.2011-2022" class="extiw external" title="doi:10.1210/jc.2011-2022">doi:10.1210/jc.2011-2022</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/22013108?dopt=Abstract">PMID 22013108</a>.</li>

<li>M. I. Rosen, S. M. Shnider, G. Levinson, S. C. Hughes: <i>Shnider and Levinson's anesthesia for obstetrics.</i> Lippincott Williams & Wilkins, Hagerstown, MD 2002, ISBN 0-683-30665-0, S. 13.</li></ul>

<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>

<li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="https://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=P08185">Homologe bei OMA</a></span>

</li>

</ol></div><div><div class="zim-footer">

Dieser Artikel wurde von <a class="external text" title="Zuletzt bearbeitet am 2024-06-07" href="https://de.wikipedia.org/wiki/?title=Transcortin&oldid=245701816">Wikipedia</a> herausgegeben. Der Text ist unter <a class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.de">Creative Commons Attribution-Share Alike 4.0</a> verfügbar, sofern nicht anders angegeben. Für die Mediendateien können zusätzliche Bedingungen gelten.

</div>

</div></div>

</div>

</main>

</div>

</body></html>